How Adequan® Works

Reduce. Restore. Repair. Reverse.
Nothing works like Adequan® i.m.

As the only FDA-Approved equine i.m. PSGAG, Adequan® i.m. has a mode of action that helps treat degenerative joint disease (DJD) in multiple ways to keep joints moving. It is proven to: 1,2

  • Reduce the swelling and inflammation associated with joint disease to improve lameness
  • Restore synovial lubrication that facilitates movement and reduces local inflammation
  • Repair cartilage and rapidly aid in the production of new cartilage
  • Reverse the disease cycle that leads the loss of cartilage components by inhibiting harmful enzymes that attack cartilage and synovial fluid
Adequan Equine brown horse riding in autumn HR

See how it works like no other drug product

INDICATIONS

Adequan® i.m. (polysulfated glycosaminoglycan) is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses.

Healthy joint

adequan healthyJoint Bone RT Mask

The ends of the bones are covered by articular cartilage which acts as a shock absorber.3


Diseased joint

adequan diseased Joint Bone Right Mask

With cartilage loss, the joint space narrows and bone rubs on bone causing pain, inflammation and decreased range of motion.3

Start early before cartilage is irreparably damaged.

DJD is a progressive condition that worsens if left untreated. This can result in irreversible changes in the joint, including loss of key cartilage components that are essential to healthy mobility. Once a diagnosis is made, a horse needs a treatment plan focused on inhibiting the destructive processes of DJD before mobility is compromised.


Three decades of trust.

For 30 years, leading veterinarians, riders, trainers and horse enthusiasts have relied on Adequan® i.m. to keep their horses moving through competitions, training and everyday life. Words that come from their experiences and hearts communicate the benefits best.

Discover if Adequan® i.m. is the right choice.

INDICATIONS Adequan® i.m. (polysulfated glycosaminoglycan) is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses.
IMPORTANT SAFETY INFORMATION There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan. Studies have not been conducted to establish safety in breeding horses. WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For full prescribing information, click here.
1. Adequan® i.m. Package Insert, Rev 1/19.
2. Burba DJ, Collier MA, DeBault LE, Hanson-Painton O, Thompson HC, Holder CL: In vivo kinetic study on uptake and distribution of intramuscular tritium-labeled polysulfated glycosaminoglycan in equine body fluid compartments and articular cartilage in an osteochondral defect model. J Equine Vet Sci 1993; 13: 696-703.
3. Kawcak CE, Barrett MF, Werpy NM, Selberg K. 2016. General Principles of Diagnosis and Treatment. Joint Disease in the Horse. 2nd edition: Pg. 119-133. ISBN: 978-1-4557-5969-9.

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