Adequan® i.m. is the ONLY FDA approved equine polysulfated glycosaminoglycan (PSGAG) for the intramuscular treatment of non-infectious degenerative joint disease (DJD) of the carpal and hock joints proven to:
DIMINISH the destructive processes of degenerative joint disease1 REVERSE the processes which result in the loss of cartilage components1 IMPROVE overall joint function and associated lameness1

1. Adequan® i.m. [package insert] Shirley, NY : Luitpold Animal Health: 2008.
INDICATIONS Adequan® i.m. (polysulfated glycosaminoglycan) is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. IMPORTANT SAFETY INFORMATION There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan. Studies have not been conducted to establish safety in breeding horses. WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequan® I.A. Brand of Polysulfated Glycosaminoglycan (PSGAG)
For intra-articular use only.
INDICATIONS Adequan is recommended for the treatment of non-infectious degenerative and /or traumatic joint dysfunction and associated lameness of the carpal joint in horses. IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS: Do not use in horses showing hypersensitivity to Polysulfated Glycosaminoglycan. Do not administer in the face of joint sepsis. WARNING: Do not use in horses intended for human consumption.
ADVERSE REACTIONS: Inflammatory joint reactions and septic arthritis have been reported following administration of Adequan® I.A. PRECAUTIONS: Use only in the carpal joint of horses. Joint sepsis, a rare but potentially life threatening complication, can occur after intra-articular injection. Do not use in horses intended for breeding. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
How It Works
Adequan® i.m. is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses.
Adequan® i.m. works in a variety of ways to:
2. Burba DJ, Collier MA, Default LE, Hanson-Painton O, Thompson HC, Holder CL: In vivo kinetic study on uptake and distribution of intramuscular tritium-labeled polysulfated glycosaminoglycan in equine body fluid compartments and articulary cartilage in an osteochondral defect model. The Journal of Equine Veterinary Science 1993; 696-703.
INDICATIONS Adequan® i.m. (polysulfated glycosaminoglycan) is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. IMPORTANT SAFETY INFORMATION There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan. Studies have not been conducted to establish safety in breeding horses. WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequan® I.A. Brand of Polysulfated Glycosaminoglycan (PSGAG)
For intra-articular use only.
INDICATIONS Adequan is recommended for the treatment of non-infectious degenerative and /or traumatic joint dysfunction and associated lameness of the carpal joint in horses. IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS: Do not use in horses showing hypersensitivity to Polysulfated Glycosaminoglycan. Do not administer in the face of joint sepsis. WARNING: Do not use in horses intended for human consumption.
ADVERSE REACTIONS: Inflammatory joint reactions and septic arthritis have been reported following administration of Adequan® I.A. PRECAUTIONS: Use only in the carpal joint of horses. Joint sepsis, a rare but potentially life threatening complication, can occur after intra-articular injection. Do not use in horses intended for breeding. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dosing & Administration
Adequan® i.m. is well-absorbed after a single intramuscular injection2


Clinical significance of the above results is unknown.
For Example:
Dosing & Administration*
  • Administer 1 intramuscular injection (500 mg)
  • Every 4 days
  • For 7 treatments
  • Consult with your veterinarian regarding any questions on dosing
*Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Adequan® i.m. Dose Response Study3 and the benefits of adhering to the labeled dosing regimen:


2. Burba DJ, Collier MA, Default LE, Hanson-Painton O, Thompson HC, Holder CL: In vivo kinetic study on uptake and distribution of intramuscular tritium-labeled polysulfated glycosaminoglycan in equine body fluid compartments and articulary cartilage in an osteochondral defect model. The Journal of Equine Veterinary Science 1993; 696-703. 3. Freedom of Information Summary, Adequan® i.m. NADA 140-901 http://www.fda.gov/animalveterinary/products/approvedanimaldrugproducts/foiadrugsummaries/ucm054843.htm Accessed October 26, 2010.
INDICATIONS Adequan® i.m. (polysulfated glycosaminoglycan) is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. IMPORTANT SAFETY INFORMATION There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan. Studies have not been conducted to establish safety in breeding horses. WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequan® I.A. Brand of Polysulfated Glycosaminoglycan (PSGAG)
For intra-articular use only.
INDICATIONS Adequan is recommended for the treatment of non-infectious degenerative and /or traumatic joint dysfunction and associated lameness of the carpal joint in horses. IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS: Do not use in horses showing hypersensitivity to Polysulfated Glycosaminoglycan. Do not administer in the face of joint sepsis. WARNING: Do not use in horses intended for human consumption.
ADVERSE REACTIONS: Inflammatory joint reactions and septic arthritis have been reported following administration of Adequan® I.A. PRECAUTIONS: Use only in the carpal joint of horses. Joint sepsis, a rare but potentially life threatening complication, can occur after intra-articular injection. Do not use in horses intended for breeding. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
FDA Approval


Adequan® is an FDA Approved Pioneer Drug FDA Pioneer Drug:4
  • A drug that has been rigorously tested by undergoing blinded and controlled clinical safety and efficacy studies in accordance with FDA mandated standards set forth as Good Laboratory Practices (GLPs)
  • The product is manufactured under FDA mandated Good Manufacturing Practices (GMPs) in regularly inspected plants
  • Therapeutic consistency, product quality, accurate shelf life, and scientifically substantiated labeling are FDA mandated
  • Stringent standards for drug potency and purity must be established and stability data generated to determine expiration dating
  • Detailed records of each batch of drug produced are maintained and retained for future testing
  • The manufacturer conducts ongoing surveillance for adverse events involving lack of safety or efficacy and must regularly provide reporting data to FDA
  • There is No Generic Adequan
  • How to identify an FDA Approved Drug?
    • All FDA-approved veterinary pharmaceutical pioneer products carry a six-digit New Animal Drug Application (NADA) number. Most drug manufacturers list the number and the statement, "Approved by FDA," on the drug's label.




4. Equine Veterinary Compounding Guidelines. American Association of Equine Practitioners website. http://www.aaep.org/custdocs/drug_compounding_guidelines.pdf. Accessed March 6, 2017.
INDICATIONS Adequan® i.m. (polysulfated glycosaminoglycan) is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. IMPORTANT SAFETY INFORMATION There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan. Studies have not been conducted to establish safety in breeding horses. WARNING: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequan® I.A. Brand of Polysulfated Glycosaminoglycan (PSGAG)
For intra-articular use only.
INDICATIONS Adequan is recommended for the treatment of non-infectious degenerative and /or traumatic joint dysfunction and associated lameness of the carpal joint in horses. IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS: Do not use in horses showing hypersensitivity to Polysulfated Glycosaminoglycan. Do not administer in the face of joint sepsis. WARNING: Do not use in horses intended for human consumption.
ADVERSE REACTIONS: Inflammatory joint reactions and septic arthritis have been reported following administration of Adequan® I.A. PRECAUTIONS: Use only in the carpal joint of horses. Joint sepsis, a rare but potentially life threatening complication, can occur after intra-articular injection. Do not use in horses intended for breeding. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Resources

Adequan® i.m. Facts Brochure


Technical Bulletin - Adequan® i.m.
Dosing Regimen



Technical Bulletin - FDA Approved
Drugs vs. Compounded Products







Adequan® I.A.
Adequan® I.A.
Adequan® is recommended for the treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal joint in horses.
Dosing and Administration
  • 250 mg (1 vial) once a week for five weeks, intra-articularly.

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Adequan® I.A. Brand of Polysulfated Glycosaminoglycan (PSGAG)
For intra-articular use only.
INDICATIONS Adequan is recommended for the treatment of non-infectious degenerative and /or traumatic joint dysfunction and associated lameness of the carpal joint in horses. IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS: Do not use in horses showing hypersensitivity to Polysulfated Glycosaminoglycan. Do not administer in the face of joint sepsis. WARNING: Do not use in horses intended for human consumption.
ADVERSE REACTIONS: Inflammatory joint reactions and septic arthritis have been reported following administration of Adequan® I.A. PRECAUTIONS: Use only in the carpal joint of horses. Joint sepsis, a rare but potentially life threatening complication, can occur after intra-articular injection. Do not use in horses intended for breeding. Keep this and all medications out of the reach of children. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Contact & Ordering Info


Call Customer Service Today! Or use our Online ordering system for veterinarians Purchase Adequan® Online Now!
(800) 458-0163
Online ordering system for veterinarians Purchase Adequan® Online Now!

Or Call Customer Service Today! (800) 458-0163


Customer Service: To place an order, check an order status, inquire about pricing, process a return, or general information.

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Adequan® and the Horse Head design are registered trademarks of Luitpold Pharmaceuticals, Inc.
¬©Luitpold Animal Health, division of Luitpold Pharmaceuticals, Inc. 2017. Luitpold Animal Health website, PP-AA-US-0015      6/2017